2s.io

https://2s.io/api/gov/fda-drug-events

Shares a payout wallet with 441 other endpoints — its adoption is attributed from that shared wallet's traffic, not earned exclusively.

Adverse drug event reports from FDA's Adverse Event Reporting System (FAERS) — 9M+ records since 1968 covering serious adverse events, hospitalizations, deaths, and disabilities. Search by drug name (brand/generic/substance, all OR-matched) and optionally filter by MedDRA reaction term. Returns report ID, received date, seriousness flags, patient demographics, MedDRA-coded reactions, implicated drugs (up to 5 per report), and reporting country. Backed by OpenFDA; data is public-domain US government records.

reliability

Reliability & health

Uptime and response time from our own unpaid probes, plus the reliability score built from them.

7 days 30 days

Uptime

100.0% avg

Response time

p50 61ms · p95 255ms

Data table

Reliability history per time bucket over the last 7 days (hourly).
Bucket	Uptime	Probes	Response time
8/15/2026, 5:00:00 AM	100%	1	60ms
8/15/2026, 6:00:00 AM	100%	1	55ms
8/15/2026, 7:00:00 AM	100%	1	93ms
8/15/2026, 8:00:00 AM	100%	1	56ms
8/15/2026, 9:00:00 AM	100%	1	50ms
8/15/2026, 10:00:00 AM	100%	1	66ms
8/15/2026, 11:00:00 AM	100%	1	231ms
8/15/2026, 1:00:00 PM	100%	1	99ms
8/15/2026, 2:00:00 PM	100%	1	54ms
8/15/2026, 3:00:00 PM	100%	1	60ms
8/15/2026, 4:00:00 PM	100%	1	53ms
8/15/2026, 5:00:00 PM	100%	1	52ms
8/15/2026, 6:00:00 PM	100%	1	294ms
8/15/2026, 8:00:00 PM	100%	1	51ms
8/15/2026, 9:00:00 PM	100%	1	58ms
8/15/2026, 10:00:00 PM	100%	1	45ms
8/15/2026, 11:00:00 PM	100%	1	49ms
8/16/2026, 12:00:00 AM	100%	1	52ms
8/16/2026, 1:00:00 AM	100%	1	52ms
8/16/2026, 3:00:00 AM	100%	1	61ms
8/16/2026, 4:00:00 AM	100%	1	121ms
8/16/2026, 5:00:00 AM	100%	1	59ms
8/16/2026, 6:00:00 AM	100%	1	110ms
8/16/2026, 7:00:00 AM	100%	1	59ms
8/16/2026, 8:00:00 AM	100%	1	46ms
8/16/2026, 10:00:00 AM	100%	1	44ms
8/16/2026, 11:00:00 AM	100%	1	52ms
8/16/2026, 12:00:00 PM	100%	1	69ms
8/16/2026, 1:00:00 PM	100%	1	58ms
8/16/2026, 2:00:00 PM	100%	1	66ms
8/16/2026, 3:00:00 PM	100%	1	57ms
8/16/2026, 5:00:00 PM	100%	1	57ms
8/16/2026, 6:00:00 PM	100%	1	62ms
8/16/2026, 7:00:00 PM	100%	1	69ms
8/16/2026, 8:00:00 PM	100%	1	70ms
8/16/2026, 9:00:00 PM	100%	1	61ms
8/16/2026, 10:00:00 PM	100%	1	69ms
8/17/2026, 12:00:00 AM	100%	1	67ms
8/17/2026, 1:00:00 AM	100%	1	106ms
8/17/2026, 2:00:00 AM	100%	1	82ms
8/17/2026, 3:00:00 AM	100%	1	55ms
8/17/2026, 4:00:00 AM	100%	1	54ms
8/17/2026, 5:00:00 AM	100%	1	52ms
8/17/2026, 7:00:00 AM	100%	1	54ms
8/17/2026, 8:00:00 AM	100%	1	64ms
8/17/2026, 9:00:00 AM	100%	1	68ms
8/17/2026, 10:00:00 AM	100%	1	60ms
8/17/2026, 11:00:00 AM	100%	1	199ms
8/17/2026, 12:00:00 PM	100%	1	251ms
8/17/2026, 2:00:00 PM	100%	1	171ms
8/17/2026, 3:00:00 PM	100%	1	46ms
8/17/2026, 4:00:00 PM	100%	1	66ms
8/17/2026, 5:00:00 PM	100%	1	47ms
8/17/2026, 6:00:00 PM	100%	1	54ms
8/17/2026, 7:00:00 PM	100%	1	59ms
8/17/2026, 9:00:00 PM	100%	1	61ms
8/17/2026, 10:00:00 PM	100%	1	51ms
8/17/2026, 11:00:00 PM	100%	1	51ms
8/18/2026, 12:00:00 AM	100%	1	134ms
8/18/2026, 1:00:00 AM	100%	1	55ms
8/18/2026, 2:00:00 AM	100%	1	61ms
8/18/2026, 4:00:00 AM	100%	1	67ms
8/18/2026, 5:00:00 AM	100%	1	50ms
8/18/2026, 6:00:00 AM	100%	1	127ms
8/18/2026, 7:00:00 AM	100%	1	72ms
8/18/2026, 8:00:00 AM	100%	1	51ms
8/18/2026, 9:00:00 AM	100%	1	64ms
8/18/2026, 11:00:00 AM	100%	1	52ms
8/18/2026, 12:00:00 PM	100%	1	56ms
8/18/2026, 1:00:00 PM	100%	1	52ms
8/18/2026, 2:00:00 PM	100%	1	59ms
8/18/2026, 3:00:00 PM	100%	1	71ms
8/18/2026, 4:00:00 PM	100%	1	68ms
8/18/2026, 6:00:00 PM	100%	1	53ms
8/18/2026, 7:00:00 PM	100%	1	62ms
8/18/2026, 8:00:00 PM	100%	1	95ms
8/18/2026, 9:00:00 PM	100%	1	55ms
8/18/2026, 10:00:00 PM	100%	1	51ms
8/18/2026, 11:00:00 PM	100%	1	52ms
8/19/2026, 1:00:00 AM	100%	1	47ms
8/19/2026, 2:00:00 AM	100%	1	59ms
8/19/2026, 3:00:00 AM	100%	1	78ms
8/19/2026, 4:00:00 AM	100%	1	62ms
8/19/2026, 5:00:00 AM	100%	1	61ms
8/19/2026, 6:00:00 AM	100%	1	56ms
8/19/2026, 8:00:00 AM	100%	1	256ms
8/19/2026, 9:00:00 AM	100%	1	79ms
8/19/2026, 10:00:00 AM	100%	1	45ms
8/19/2026, 11:00:00 AM	100%	1	67ms
8/19/2026, 12:00:00 PM	100%	1	54ms
8/19/2026, 1:00:00 PM	100%	1	66ms
8/19/2026, 3:00:00 PM	100%	2	60ms
8/19/2026, 4:00:00 PM	100%	1	69ms
8/19/2026, 5:00:00 PM	100%	1	73ms
8/19/2026, 6:00:00 PM	100%	1	56ms
8/19/2026, 7:00:00 PM	100%	1	55ms
8/19/2026, 8:00:00 PM	100%	1	61ms
8/19/2026, 9:00:00 PM	100%	1	55ms
8/19/2026, 11:00:00 PM	100%	1	60ms
8/20/2026, 12:00:00 AM	100%	1	54ms
8/20/2026, 1:00:00 AM	100%	1	66ms
8/20/2026, 2:00:00 AM	100%	1	57ms
8/20/2026, 3:00:00 AM	100%	1	50ms
8/20/2026, 4:00:00 AM	100%	1	57ms
8/20/2026, 6:00:00 AM	100%	1	67ms
8/20/2026, 7:00:00 AM	100%	1	72ms
8/20/2026, 8:00:00 AM	100%	1	62ms
8/20/2026, 9:00:00 AM	100%	1	256ms
8/20/2026, 10:00:00 AM	100%	1	65ms
8/20/2026, 11:00:00 AM	100%	1	61ms
8/20/2026, 1:00:00 PM	100%	1	108ms
8/20/2026, 2:00:00 PM	100%	1	64ms
8/20/2026, 3:00:00 PM	100%	1	273ms
8/20/2026, 4:00:00 PM	100%	1	59ms
8/20/2026, 6:00:00 PM	100%	1	51ms
8/20/2026, 7:00:00 PM	100%	1	54ms
8/20/2026, 8:00:00 PM	100%	1	75ms
8/20/2026, 9:00:00 PM	100%	1	58ms
8/20/2026, 10:00:00 PM	100%	1	53ms
8/20/2026, 11:00:00 PM	100%	1	52ms
8/21/2026, 1:00:00 AM	100%	1	287ms
8/21/2026, 2:00:00 AM	100%	1	62ms
8/21/2026, 3:00:00 AM	100%	1	57ms
8/21/2026, 4:00:00 AM	100%	1	77ms
8/21/2026, 5:00:00 AM	100%	1	52ms
8/21/2026, 6:00:00 AM	100%	1	52ms
8/21/2026, 7:00:00 AM	100%	1	68ms
8/21/2026, 9:00:00 AM	100%	1	100ms
8/21/2026, 10:00:00 AM	100%	1	55ms
8/21/2026, 11:00:00 AM	100%	1	53ms
8/21/2026, 12:00:00 PM	100%	1	50ms
8/21/2026, 1:00:00 PM	100%	1	173ms
8/21/2026, 2:00:00 PM	100%	1	55ms
8/21/2026, 3:00:00 PM	100%	1	278ms
8/21/2026, 5:00:00 PM	100%	1	381ms
8/21/2026, 6:00:00 PM	100%	1	345ms
8/21/2026, 7:00:00 PM	100%	1	103ms
8/21/2026, 8:00:00 PM	100%	1	65ms
8/21/2026, 9:00:00 PM	100%	1	67ms
8/21/2026, 10:00:00 PM	100%	1	124ms
8/21/2026, 11:00:00 PM	100%	1	67ms
8/22/2026, 1:00:00 AM	100%	1	132ms
8/22/2026, 2:00:00 AM	100%	1	129ms
8/22/2026, 3:00:00 AM	100%	1	65ms

Composite reliability — the weighted average of the dimensions below, on a 0–100 scale.

Availability: 100
Latency: 100
Security: 100
Transparency: 61
Activity: 2

Confidence 100% — how much probe evidence backs this score. A thin history is flagged, not hidden.

See the scoring methodology for exactly how each number is computed.

Payment

Currencies: USDC
Networks: base, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp
Facilitator: unknown
SDK: unknown

Operator

Company: inferred — unknown
Jurisdiction: —
Registrar: —
Domain registered: —
Hosting network: VERCEL-09
Hosting country: —

Operator context is derived from public RDAP/TLS records and unverified. Company and country are only available for endpoints that publish them (an OV/EV TLS certificate or a non-redacted domain record); most endpoints are CDN-fronted and disclose neither.

On-chain activity (base)

12,279

payments (30d)

35.43

USD volume (30d)

181

paying wallets (30d)

Payments per day

last payment 8/21/2026

Data table

Settled payments per day.
Day	Payments	Volume (USD)	Paying wallets
7/24/2026	1,232	2.49	117
7/25/2026	1,341	2.61	128
7/26/2026	915	1.98	107
7/27/2026	1,175	2.1	107
7/28/2026	762	1.71	86
7/29/2026	852	1.67	97
7/30/2026	818	1.74	97
7/31/2026	882	1.7	94
8/1/2026	633	1.24	82
8/2/2026	604	1.12	76
8/3/2026	358	1.6	47
8/4/2026	530	3.35	70
8/5/2026	408	2.76	42
8/6/2026	272	2.14	32
8/7/2026	164	1.37	23
8/8/2026	127	1.51	17
8/9/2026	60	0.33	10
8/10/2026	109	0.36	8
8/11/2026	84	0.25	8
8/12/2026	84	0.25	6
8/13/2026	73	0.21	6
8/14/2026	167	1.05	6
8/15/2026	24	0.1	4
8/16/2026	338	0.86	2
8/17/2026	63	0.18	3
8/18/2026	55	0.16	2
8/19/2026	84	0.23	3
8/20/2026	43	0.25	6
8/21/2026	22	0.1	5

This payout wallet is shared: figures cover all 442 endpoints paid at it, since payments cannot be attributed to one of them. Only payments settled on chains and facilitators we index.

Linked by wallet — likely same operator

On-chain agent identity and the x402 endpoint that shares its settlement wallet.

https://2s.io/api/crypto/ens-resolve x402 endpoint https://2s-3cpr6qm6j-alleyford.vercel.app/api/convert/unit x402 endpoint

Response schema

{
  "properties": {
    "data": {
      "additionalProperties": false,
      "properties": {
        "items": {
          "items": {
            "additionalProperties": false,
            "properties": {
              "death": {
                "type": "boolean"
              },
              "disabling": {
                "type": "boolean"
              },
              "drugs": {
                "items": {
                  "additionalProperties": false,
                  "properties": {
                    "brandName": {
                      "nullable": true,
                      "type": "string"
                    },
                    "dosageText": {
                      "nullable": true,
                      "type": "string"
                    },
                    "indication": {
                      "nullable": true,
                      "type": "string"
                    },
                    "medicinalProduct": {
                      "nullable": true,
                      "type": "string"
                    }
                  },
                  "required": [
                    "medicinalProduct",
                    "brandName",
                    "indication",
                    "dosageText"
                  ],
                  "type": "object"
                },
                "type": "array"
              },
              "hospitalization": {
                "type": "boolean"
              },
              "lifeThreatening": {
                "type": "boolean"
              },
              "occurCountry": {
                "nullable": true,
                "type": "string"
              },
              "patientAge": {
                "nullable": true,
                "type": "string"
              },
              "patientSex": {
                "nullable": true,
                "type": "string"
              },
              "reactions": {
                "items": {
                  "type": "string"
                },
                "type": "array"
              },
              "receivedDate": {
                "nullable": true,
                "type": "string"
              },
              "safetyReportId": {
                "type": "string"
              },
              "serious": {
                "type": "boolean"
              }
            },
            "required": [
              "safetyReportId",
              "receivedDate",
              "serious",
              "hospitalization",
              "death",
              "disabling",
              "lifeThreatening",
              "patientSex",
              "patientAge",
              "reactions",
              "drugs",
              "occurCountry"
            ],
            "type": "object"
          },
          "type": "array"
        },
        "meta": {
          "additionalProperties": false,
          "properties": {
            "query": {
              "additionalProperties": false,
              "properties": {
                "drug": {
                  "type": "string"
                },
                "limit": {
                  "type": "integer"
                },
                "reaction": {
                  "nullable": true,
                  "type": "string"
                }
              },
              "required": [
                "drug",
                "reaction",
                "limit"
              ],
              "type": "object"
            }
          },
          "required": [
            "query"
          ],
          "type": "object"
        },
        "ok": {
          "enum": [
            true
          ],
          "type": "boolean"
        },
        "source": {
          "$ref": "#/components/schemas/Source"
        },
        "total": {
          "description": "Total matching rows upstream; null when unknown.",
          "nullable": true,
          "type": "integer"
        }
      },
      "required": [
        "ok",
        "items",
        "total",
        "source"
      ],
      "type": "object"
    },
    "meta": {
      "$ref": "#/components/schemas/CallMeta"
    }
  },
  "required": [
    "data",
    "meta"
  ],
  "type": "object"
}