2s.io

https://2s.io/api/bio/protein

Shares a payout wallet with 441 other endpoints — its adoption is attributed from that shared wallet's traffic, not earned exclusively.

Look up a protein in UniProtKB by accession (e.g. "P04637", "Q9Y6K9", "P0DTC2"). Returns the entry id, reviewed (Swiss-Prot) flag, recommended + alternative protein names, gene names, organism + taxid, sequence length and molecular weight, the curated function description, subcellular locations, Gene Ontology terms (id + term + aspect: biological_process / molecular_function / cellular_component), PDB structure ids, and keywords. Bioinformatics, structural biology, drug-target research, education. Gene-centric sibling: /api/bio/gene. CC-BY UniProt data.

63
reliability

Reliability & health

Uptime and response time from our own unpaid probes, plus the reliability score built from them.

7 days 30 days

Uptime

100.0% avg
0% 50% 100% Sat 1 AMMon 9 AMWed 4 PMFri 11 PM

Response time

p50 62ms · p95 217ms
0ms 200ms 400ms Sat 1 AMMon 9 AMWed 4 PMFri 11 PM
Data table
Reliability history per time bucket over the last 7 days (hourly).
Bucket Uptime Probes Response time
8/15/2026, 1:00:00 AM 100% 1 225ms
8/15/2026, 2:00:00 AM 100% 1 187ms
8/15/2026, 3:00:00 AM 100% 1 103ms
8/15/2026, 5:00:00 AM 100% 1 100ms
8/15/2026, 6:00:00 AM 100% 1 109ms
8/15/2026, 7:00:00 AM 100% 1 111ms
8/15/2026, 8:00:00 AM 100% 1 105ms
8/15/2026, 9:00:00 AM 100% 1 48ms
8/15/2026, 10:00:00 AM 100% 1 83ms
8/15/2026, 11:00:00 AM 100% 1 161ms
8/15/2026, 12:00:00 PM 100% 1 50ms
8/15/2026, 2:00:00 PM 100% 1 58ms
8/15/2026, 3:00:00 PM 100% 1 63ms
8/15/2026, 4:00:00 PM 100% 1 73ms
8/15/2026, 5:00:00 PM 100% 1 64ms
8/15/2026, 6:00:00 PM 100% 1 47ms
8/15/2026, 7:00:00 PM 100% 1 103ms
8/15/2026, 9:00:00 PM 100% 1 52ms
8/15/2026, 10:00:00 PM 100% 1 234ms
8/15/2026, 11:00:00 PM 100% 1 48ms
8/16/2026, 12:00:00 AM 100% 1 109ms
8/16/2026, 1:00:00 AM 100% 1 53ms
8/16/2026, 2:00:00 AM 100% 1 62ms
8/16/2026, 4:00:00 AM 100% 1 62ms
8/16/2026, 5:00:00 AM 100% 1 53ms
8/16/2026, 6:00:00 AM 100% 1 82ms
8/16/2026, 7:00:00 AM 100% 1 62ms
8/16/2026, 8:00:00 AM 100% 1 49ms
8/16/2026, 9:00:00 AM 100% 1 116ms
8/16/2026, 11:00:00 AM 100% 1 63ms
8/16/2026, 12:00:00 PM 100% 1 55ms
8/16/2026, 1:00:00 PM 100% 1 54ms
8/16/2026, 2:00:00 PM 100% 1 57ms
8/16/2026, 3:00:00 PM 100% 1 68ms
8/16/2026, 4:00:00 PM 100% 1 69ms
8/16/2026, 6:00:00 PM 100% 1 47ms
8/16/2026, 7:00:00 PM 100% 1 57ms
8/16/2026, 8:00:00 PM 100% 1 58ms
8/16/2026, 9:00:00 PM 100% 1 58ms
8/16/2026, 10:00:00 PM 100% 1 47ms
8/16/2026, 11:00:00 PM 100% 1 114ms
8/17/2026, 1:00:00 AM 100% 1 57ms
8/17/2026, 2:00:00 AM 100% 1 299ms
8/17/2026, 3:00:00 AM 100% 1 61ms
8/17/2026, 4:00:00 AM 100% 1 62ms
8/17/2026, 5:00:00 AM 100% 1 60ms
8/17/2026, 6:00:00 AM 100% 1 209ms
8/17/2026, 8:00:00 AM 100% 1 138ms
8/17/2026, 9:00:00 AM 100% 1 61ms
8/17/2026, 10:00:00 AM 100% 1 61ms
8/17/2026, 11:00:00 AM 100% 1 113ms
8/17/2026, 12:00:00 PM 100% 1 370ms
8/17/2026, 1:00:00 PM 100% 1 65ms
8/17/2026, 3:00:00 PM 100% 1 51ms
8/17/2026, 4:00:00 PM 100% 1 118ms
8/17/2026, 5:00:00 PM 100% 1 59ms
8/17/2026, 6:00:00 PM 100% 1 57ms
8/17/2026, 7:00:00 PM 100% 1 169ms
8/17/2026, 8:00:00 PM 100% 1 52ms
8/17/2026, 10:00:00 PM 100% 1 53ms
8/17/2026, 11:00:00 PM 100% 1 65ms
8/18/2026, 12:00:00 AM 100% 1 79ms
8/18/2026, 1:00:00 AM 100% 1 54ms
8/18/2026, 2:00:00 AM 100% 1 60ms
8/18/2026, 3:00:00 AM 100% 1 49ms
8/18/2026, 5:00:00 AM 100% 1 63ms
8/18/2026, 6:00:00 AM 100% 1 58ms
8/18/2026, 7:00:00 AM 100% 1 63ms
8/18/2026, 8:00:00 AM 100% 1 68ms
8/18/2026, 9:00:00 AM 100% 1 53ms
8/18/2026, 10:00:00 AM 100% 1 66ms
8/18/2026, 12:00:00 PM 100% 1 83ms
8/18/2026, 1:00:00 PM 100% 1 58ms
8/18/2026, 2:00:00 PM 100% 1 268ms
8/18/2026, 3:00:00 PM 100% 1 62ms
8/18/2026, 4:00:00 PM 100% 1 55ms
8/18/2026, 5:00:00 PM 100% 1 67ms
8/18/2026, 7:00:00 PM 100% 1 113ms
8/18/2026, 8:00:00 PM 100% 1 55ms
8/18/2026, 9:00:00 PM 100% 1 67ms
8/18/2026, 10:00:00 PM 100% 1 50ms
8/18/2026, 11:00:00 PM 100% 1 56ms
8/19/2026, 12:00:00 AM 100% 1 48ms
8/19/2026, 2:00:00 AM 100% 1 68ms
8/19/2026, 3:00:00 AM 100% 1 130ms
8/19/2026, 4:00:00 AM 100% 1 78ms
8/19/2026, 5:00:00 AM 100% 1 47ms
8/19/2026, 6:00:00 AM 100% 1 50ms
8/19/2026, 7:00:00 AM 100% 1 56ms
8/19/2026, 9:00:00 AM 100% 1 72ms
8/19/2026, 10:00:00 AM 100% 1 62ms
8/19/2026, 11:00:00 AM 100% 1 49ms
8/19/2026, 12:00:00 PM 100% 1 45ms
8/19/2026, 1:00:00 PM 100% 1 58ms
8/19/2026, 2:00:00 PM 100% 1 45ms
8/19/2026, 4:00:00 PM 100% 1 49ms
8/19/2026, 5:00:00 PM 100% 1 71ms
8/19/2026, 6:00:00 PM 100% 1 83ms
8/19/2026, 7:00:00 PM 100% 1 46ms
8/19/2026, 8:00:00 PM 100% 1 118ms
8/19/2026, 9:00:00 PM 100% 1 50ms
8/19/2026, 11:00:00 PM 100% 1 223ms
8/20/2026, 12:00:00 AM 100% 1 70ms
8/20/2026, 1:00:00 AM 100% 1 177ms
8/20/2026, 2:00:00 AM 100% 1 61ms
8/20/2026, 3:00:00 AM 100% 1 58ms
8/20/2026, 4:00:00 AM 100% 1 82ms
8/20/2026, 6:00:00 AM 100% 1 187ms
8/20/2026, 7:00:00 AM 100% 1 60ms
8/20/2026, 8:00:00 AM 100% 1 56ms
8/20/2026, 9:00:00 AM 100% 1 58ms
8/20/2026, 10:00:00 AM 100% 1 78ms
8/20/2026, 11:00:00 AM 100% 1 48ms
8/20/2026, 1:00:00 PM 100% 1 201ms
8/20/2026, 2:00:00 PM 100% 1 174ms
8/20/2026, 3:00:00 PM 100% 1 68ms
8/20/2026, 4:00:00 PM 100% 1 58ms
8/20/2026, 6:00:00 PM 100% 1 60ms
8/20/2026, 7:00:00 PM 100% 1 63ms
8/20/2026, 8:00:00 PM 100% 1 75ms
8/20/2026, 9:00:00 PM 100% 1 54ms
8/20/2026, 10:00:00 PM 100% 1 56ms
8/20/2026, 11:00:00 PM 100% 1 160ms
8/21/2026, 12:00:00 AM 100% 1 58ms
8/21/2026, 1:00:00 AM 100% 2 70ms
8/21/2026, 2:00:00 AM 100% 1 64ms
8/21/2026, 3:00:00 AM 100% 1 65ms
8/21/2026, 5:00:00 AM 100% 1 60ms
8/21/2026, 6:00:00 AM 100% 1 58ms
8/21/2026, 7:00:00 AM 100% 1 54ms
8/21/2026, 8:00:00 AM 100% 1 67ms
8/21/2026, 9:00:00 AM 100% 1 48ms
8/21/2026, 10:00:00 AM 100% 1 47ms
8/21/2026, 12:00:00 PM 100% 1 51ms
8/21/2026, 1:00:00 PM 100% 1 274ms
8/21/2026, 2:00:00 PM 100% 1 64ms
8/21/2026, 3:00:00 PM 100% 1 63ms
8/21/2026, 4:00:00 PM 100% 1 62ms
8/21/2026, 5:00:00 PM 100% 1 58ms
8/21/2026, 7:00:00 PM 100% 1 59ms
8/21/2026, 8:00:00 PM 100% 2 60ms
8/21/2026, 9:00:00 PM 100% 1 55ms
8/21/2026, 10:00:00 PM 100% 1 50ms
8/21/2026, 11:00:00 PM 100% 1 220ms
63
Composite reliability — the weighted average of the dimensions below, on a 0–100 scale.
Availability
100

How often it was reachable when we probed it (weight 35%).

Latency
100

How quickly it answers when it is up — fast scores high (weight 20%).

Security
100

Whether it serves over working TLS / https (weight 15%).

Transparency
61

Whether the operator disclosed what it does — description, schema, identity (weight 15%).

Activity
2

Observed on-chain payments to this endpoint's wallet — transactions, volume, and distinct paying wallets over the last month (weight 15%; not yet measured when we have not seen its wallet settle).

Confidence 100% — how much probe evidence backs this score. A thin history is flagged, not hidden.

See the scoring methodology for exactly how each number is computed.

Payment

Currencies
USDC
Networks
base, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp
Facilitator
unknown
SDK
unknown

Operator

Company
inferred — unknown
Jurisdiction
—
Registrar
—
Domain registered
—
Hosting network
VERCEL-09
Hosting country
—

Operator context is derived from public RDAP/TLS records and unverified. Company and country are only available for endpoints that publish them (an OV/EV TLS certificate or a non-redacted domain record); most endpoints are CDN-fronted and disclose neither.

On-chain activity (base)

12,279
payments (30d)
35.43
USD volume (30d)
181
paying wallets (30d)

Payments per day

last payment 8/21/2026
0 1000 2000 Jul 24Aug 2Aug 12Aug 21
Data table
Settled payments per day.
Day Payments Volume (USD) Paying wallets
7/24/2026 1,232 2.49 117
7/25/2026 1,341 2.61 128
7/26/2026 915 1.98 107
7/27/2026 1,175 2.1 107
7/28/2026 762 1.71 86
7/29/2026 852 1.67 97
7/30/2026 818 1.74 97
7/31/2026 882 1.7 94
8/1/2026 633 1.24 82
8/2/2026 604 1.12 76
8/3/2026 358 1.6 47
8/4/2026 530 3.35 70
8/5/2026 408 2.76 42
8/6/2026 272 2.14 32
8/7/2026 164 1.37 23
8/8/2026 127 1.51 17
8/9/2026 60 0.33 10
8/10/2026 109 0.36 8
8/11/2026 84 0.25 8
8/12/2026 84 0.25 6
8/13/2026 73 0.21 6
8/14/2026 167 1.05 6
8/15/2026 24 0.1 4
8/16/2026 338 0.86 2
8/17/2026 63 0.18 3
8/18/2026 55 0.16 2
8/19/2026 84 0.23 3
8/20/2026 43 0.25 6
8/21/2026 22 0.1 5

This payout wallet is shared: figures cover all 442 endpoints paid at it, since payments cannot be attributed to one of them. Only payments settled on chains and facilitators we index.

Linked by wallet — likely same operator

On-chain agent identity and the x402 endpoint that shares its settlement wallet.

https://2s.io/api/crypto/ens-resolve x402 endpoint https://2s-3cpr6qm6j-alleyford.vercel.app/api/convert/unit x402 endpoint
Response schema 
{
  "properties": {
    "data": {
      "additionalProperties": false,
      "properties": {
        "items": {
          "items": {
            "additionalProperties": false,
            "properties": {
              "protein": {
                "additionalProperties": false,
                "properties": {
                  "accession": {
                    "type": "string"
                  },
                  "alternativeNames": {
                    "items": {
                      "type": "string"
                    },
                    "type": "array"
                  },
                  "entryId": {
                    "nullable": true,
                    "type": "string"
                  },
                  "function": {
                    "nullable": true,
                    "type": "string"
                  },
                  "genes": {
                    "items": {
                      "type": "string"
                    },
                    "type": "array"
                  },
                  "goTerms": {
                    "items": {
                      "additionalProperties": false,
                      "properties": {
                        "aspect": {
                          "nullable": true,
                          "type": "string"
                        },
                        "id": {
                          "type": "string"
                        },
                        "term": {
                          "type": "string"
                        }
                      },
                      "required": [
                        "id",
                        "term",
                        "aspect"
                      ],
                      "type": "object"
                    },
                    "type": "array"
                  },
                  "keywords": {
                    "items": {
                      "type": "string"
                    },
                    "type": "array"
                  },
                  "lengthAa": {
                    "nullable": true,
                    "type": "number"
                  },
                  "molecularWeightDa": {
                    "nullable": true,
                    "type": "number"
                  },
                  "organism": {
                    "additionalProperties": false,
                    "nullable": true,
                    "properties": {
                      "commonName": {
                        "nullable": true,
                        "type": "string"
                      },
                      "scientificName": {
                        "nullable": true,
                        "type": "string"
                      },
                      "taxid": {
                        "nullable": true,
                        "type": "number"
                      }
                    },
                    "required": [
                      "scientificName",
                      "commonName",
                      "taxid"
                    ],
                    "type": "object"
                  },
                  "pdbStructures": {
                    "items": {
                      "type": "string"
                    },
                    "type": "array"
                  },
                  "proteinName": {
                    "nullable": true,
                    "type": "string"
                  },
                  "reviewed": {
                    "type": "boolean"
                  },
                  "subcellularLocations": {
                    "items": {
                      "type": "string"
                    },
                    "type": "array"
                  },
                  "uniprotUrl": {
                    "type": "string"
                  }
                },
                "required": [
                  "accession",
                  "entryId",
                  "reviewed",
                  "proteinName",
                  "alternativeNames",
                  "genes",
                  "organism",
                  "lengthAa",
                  "molecularWeightDa",
                  "function",
                  "subcellularLocations",
                  "goTerms",
                  "pdbStructures",
                  "keywords",
                  "uniprotUrl"
                ],
                "type": "object"
              }
            },
            "required": [
              "protein"
            ],
            "type": "object"
          },
          "type": "array"
        },
        "ok": {
          "enum": [
            true
          ],
          "type": "boolean"
        },
        "source": {
          "$ref": "#/components/schemas/Source"
        },
        "total": {
          "description": "Total matching rows upstream; null when unknown.",
          "nullable": true,
          "type": "integer"
        }
      },
      "required": [
        "ok",
        "items",
        "total",
        "source"
      ],
      "type": "object"
    },
    "meta": {
      "$ref": "#/components/schemas/CallMeta"
    }
  },
  "required": [
    "data",
    "meta"
  ],
  "type": "object"
}