2s.io

https://2s.io/api/medical/genetics

Shares a payout wallet with 441 other endpoints — its adoption is attributed from that shared wallet's traffic, not earned exclusively.

MedlinePlus Genetics (US National Library of Medicine) reference on a genetic condition or gene. Give a term (e.g. "cystic fibrosis", "BRCA1", "sickle cell") and get back the authoritative NLM record: the condition/gene name, a plain-language summary, the full set of sections (description, causes, frequency, inheritance, treatment), the inheritance pattern(s), related genes (with links), synonyms, and cross-references to other databases (OMIM, GTR, ICD-10-CM, …). Free, public-domain (NLM). Authoritative genetics reference an LLM cannot recite reliably — for clinical, patient-education, and research agents. Educational reference, not medical advice.

63
reliability

Reliability & health

Uptime and response time from our own unpaid probes, plus the reliability score built from them.

7 days 30 days

Uptime

100.0% avg
0% 50% 100% Jul 24Aug 3Aug 12Aug 22

Response time

p50 60ms · p95 147ms
0ms 100ms 200ms Jul 24Aug 3Aug 12Aug 22
Data table
Reliability history per time bucket over the last 30 days (daily).
Bucket Uptime Probes Response time
7/24/2026, 12:00:00 AM 100% 1 61ms
7/25/2026, 12:00:00 AM 100% 1 56ms
7/26/2026, 12:00:00 AM 100% 1 62ms
7/27/2026, 12:00:00 AM 100% 1 72ms
7/28/2026, 12:00:00 AM 100% 1 68ms
7/29/2026, 12:00:00 AM 100% 1 59ms
7/30/2026, 12:00:00 AM 100% 1 55ms
7/31/2026, 12:00:00 AM 100% 1 54ms
8/1/2026, 12:00:00 AM 100% 1 54ms
8/2/2026, 12:00:00 AM 100% 1 55ms
8/3/2026, 12:00:00 AM 100% 1 58ms
8/4/2026, 12:00:00 AM 100% 1 50ms
8/5/2026, 12:00:00 AM 100% 1 47ms
8/6/2026, 12:00:00 AM 100% 1 57ms
8/7/2026, 12:00:00 AM 100% 1 172ms
8/8/2026, 12:00:00 AM 100% 1 56ms
8/9/2026, 12:00:00 AM 100% 1 52ms
8/10/2026, 12:00:00 AM 100% 1 61ms
8/11/2026, 12:00:00 AM 100% 1 56ms
8/12/2026, 12:00:00 AM 100% 1 61ms
8/13/2026, 12:00:00 AM 100% 1 61ms
8/14/2026, 12:00:00 AM 100% 1 55ms
8/15/2026, 12:00:00 AM 100% 1 54ms
8/16/2026, 12:00:00 AM 100% 1 62ms
8/17/2026, 12:00:00 AM 100% 1 66ms
8/18/2026, 12:00:00 AM 100% 1 43ms
8/19/2026, 12:00:00 AM 100% 20 64ms
8/20/2026, 12:00:00 AM 100% 20 60ms
8/21/2026, 12:00:00 AM 100% 22 60ms
8/22/2026, 12:00:00 AM 100% 10 57ms
63
Composite reliability — the weighted average of the dimensions below, on a 0–100 scale.
Availability
100

How often it was reachable when we probed it (weight 35%).

Latency
100

How quickly it answers when it is up — fast scores high (weight 20%).

Security
100

Whether it serves over working TLS / https (weight 15%).

Transparency
61

Whether the operator disclosed what it does — description, schema, identity (weight 15%).

Activity
1

Observed on-chain payments to this endpoint's wallet — transactions, volume, and distinct paying wallets over the last month (weight 15%; not yet measured when we have not seen its wallet settle).

Confidence 100% — how much probe evidence backs this score. A thin history is flagged, not hidden.

See the scoring methodology for exactly how each number is computed.

Payment

Currencies
USDC
Networks
base, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp
Facilitator
unknown
SDK
unknown

Operator

Company
inferred — unknown
Jurisdiction
—
Registrar
—
Domain registered
—
Hosting network
VERCEL-09
Hosting country
—

Operator context is derived from public RDAP/TLS records and unverified. Company and country are only available for endpoints that publish them (an OV/EV TLS certificate or a non-redacted domain record); most endpoints are CDN-fronted and disclose neither.

On-chain activity (base)

12,279
payments (30d)
35.43
USD volume (30d)
181
paying wallets (30d)

Payments per day

last payment 8/21/2026
0 1000 2000 Jul 24Aug 2Aug 12Aug 21
Data table
Settled payments per day.
Day Payments Volume (USD) Paying wallets
7/24/2026 1,232 2.49 117
7/25/2026 1,341 2.61 128
7/26/2026 915 1.98 107
7/27/2026 1,175 2.1 107
7/28/2026 762 1.71 86
7/29/2026 852 1.67 97
7/30/2026 818 1.74 97
7/31/2026 882 1.7 94
8/1/2026 633 1.24 82
8/2/2026 604 1.12 76
8/3/2026 358 1.6 47
8/4/2026 530 3.35 70
8/5/2026 408 2.76 42
8/6/2026 272 2.14 32
8/7/2026 164 1.37 23
8/8/2026 127 1.51 17
8/9/2026 60 0.33 10
8/10/2026 109 0.36 8
8/11/2026 84 0.25 8
8/12/2026 84 0.25 6
8/13/2026 73 0.21 6
8/14/2026 167 1.05 6
8/15/2026 24 0.1 4
8/16/2026 338 0.86 2
8/17/2026 63 0.18 3
8/18/2026 55 0.16 2
8/19/2026 84 0.23 3
8/20/2026 43 0.25 6
8/21/2026 22 0.1 5

This payout wallet is shared: figures cover all 442 endpoints paid at it, since payments cannot be attributed to one of them. Only payments settled on chains and facilitators we index.

Linked by wallet — likely same operator

On-chain agent identity and the x402 endpoint that shares its settlement wallet.

https://2s.io/api/crypto/ens-resolve x402 endpoint https://2s-3cpr6qm6j-alleyford.vercel.app/api/convert/unit x402 endpoint
Response schema 
{
  "properties": {
    "data": {
      "additionalProperties": false,
      "properties": {
        "items": {
          "items": {
            "additionalProperties": false,
            "properties": {
              "crossReferences": {
                "items": {
                  "additionalProperties": false,
                  "properties": {
                    "db": {
                      "type": "string"
                    },
                    "key": {
                      "type": "string"
                    }
                  },
                  "required": [
                    "db",
                    "key"
                  ],
                  "type": "object"
                },
                "type": "array"
              },
              "inheritancePatterns": {
                "items": {
                  "type": "string"
                },
                "type": "array"
              },
              "name": {
                "nullable": true,
                "type": "string"
              },
              "query": {
                "additionalProperties": false,
                "properties": {
                  "slug": {
                    "nullable": true,
                    "type": "string"
                  },
                  "term": {
                    "type": "string"
                  },
                  "type": {
                    "enum": [
                      "condition",
                      "gene"
                    ],
                    "nullable": true,
                    "type": "string"
                  }
                },
                "required": [
                  "term",
                  "type",
                  "slug"
                ],
                "type": "object"
              },
              "relatedGenes": {
                "items": {
                  "additionalProperties": false,
                  "properties": {
                    "symbol": {
                      "type": "string"
                    },
                    "url": {
                      "nullable": true,
                      "type": "string"
                    }
                  },
                  "required": [
                    "symbol",
                    "url"
                  ],
                  "type": "object"
                },
                "type": "array"
              },
              "sections": {
                "items": {
                  "additionalProperties": false,
                  "properties": {
                    "role": {
                      "nullable": true,
                      "type": "string"
                    },
                    "text": {
                      "type": "string"
                    }
                  },
                  "required": [
                    "role",
                    "text"
                  ],
                  "type": "object"
                },
                "type": "array"
              },
              "summary": {
                "nullable": true,
                "type": "string"
              },
              "synonyms": {
                "items": {
                  "type": "string"
                },
                "type": "array"
              },
              "type": {
                "enum": [
                  "condition",
                  "gene"
                ],
                "nullable": true,
                "type": "string"
              },
              "url": {
                "nullable": true,
                "type": "string"
              }
            },
            "required": [
              "query",
              "type",
              "name",
              "summary",
              "sections",
              "inheritancePatterns",
              "relatedGenes",
              "synonyms",
              "crossReferences",
              "url"
            ],
            "type": "object"
          },
          "type": "array"
        },
        "ok": {
          "enum": [
            true
          ],
          "type": "boolean"
        },
        "source": {
          "$ref": "#/components/schemas/Source"
        },
        "total": {
          "description": "Total matching rows upstream; null when unknown.",
          "nullable": true,
          "type": "integer"
        }
      },
      "required": [
        "ok",
        "items",
        "total",
        "source"
      ],
      "type": "object"
    },
    "meta": {
      "$ref": "#/components/schemas/CallMeta"
    }
  },
  "required": [
    "data",
    "meta"
  ],
  "type": "object"
}