2s.io

https://2s.io/api/clinical/trial-search

Shares a payout wallet with 441 other endpoints — its adoption is attributed from that shared wallet's traffic, not earned exclusively.

Search ClinicalTrials.gov — every registered US (and many international) clinical study (~500k trials). Free-text query matches title + condition + intervention; or direct lookup by NCT ID. Optional filters: recruitment status, lead sponsor, phase (PHASE1..PHASE4), country. Each record includes NCT ID, brief + official title, status, phases, study type, conditions list, interventions (with type + name), enrollment count + type, key dates (start / primary completion / completion / first posted / last update), lead sponsor + class (INDUSTRY/NIH/OTHER), hasResults flag, brief summary, and canonical clinicaltrials.gov URL. Public-domain NIH NLM data.

63
reliability

Reliability & health

Uptime and response time from our own unpaid probes, plus the reliability score built from them.

7 days 30 days

Uptime

100.0% avg
0% 50% 100% Sat 12 AMMon 8 AMWed 2 PMFri 10 PM

Response time

p50 61ms · p95 209ms
0ms 200ms 400ms Sat 12 AMMon 8 AMWed 2 PMFri 10 PM
Data table
Reliability history per time bucket over the last 7 days (hourly).
Bucket Uptime Probes Response time
8/15/2026, 12:00:00 AM 100% 1 69ms
8/15/2026, 1:00:00 AM 100% 1 71ms
8/15/2026, 2:00:00 AM 100% 1 58ms
8/15/2026, 3:00:00 AM 100% 1 53ms
8/15/2026, 5:00:00 AM 100% 1 70ms
8/15/2026, 6:00:00 AM 100% 1 55ms
8/15/2026, 7:00:00 AM 100% 1 58ms
8/15/2026, 8:00:00 AM 100% 1 59ms
8/15/2026, 9:00:00 AM 100% 1 55ms
8/15/2026, 10:00:00 AM 100% 1 173ms
8/15/2026, 11:00:00 AM 100% 1 59ms
8/15/2026, 12:00:00 PM 100% 1 56ms
8/15/2026, 2:00:00 PM 100% 1 121ms
8/15/2026, 3:00:00 PM 100% 1 66ms
8/15/2026, 4:00:00 PM 100% 1 59ms
8/15/2026, 5:00:00 PM 100% 1 311ms
8/15/2026, 6:00:00 PM 100% 1 54ms
8/15/2026, 7:00:00 PM 100% 1 53ms
8/15/2026, 9:00:00 PM 100% 1 62ms
8/15/2026, 10:00:00 PM 100% 1 151ms
8/15/2026, 11:00:00 PM 100% 1 203ms
8/16/2026, 12:00:00 AM 100% 1 57ms
8/16/2026, 1:00:00 AM 100% 1 60ms
8/16/2026, 2:00:00 AM 100% 1 53ms
8/16/2026, 4:00:00 AM 100% 1 55ms
8/16/2026, 5:00:00 AM 100% 1 67ms
8/16/2026, 6:00:00 AM 100% 1 57ms
8/16/2026, 7:00:00 AM 100% 1 52ms
8/16/2026, 8:00:00 AM 100% 1 52ms
8/16/2026, 9:00:00 AM 100% 1 50ms
8/16/2026, 11:00:00 AM 100% 1 58ms
8/16/2026, 12:00:00 PM 100% 1 68ms
8/16/2026, 1:00:00 PM 100% 1 52ms
8/16/2026, 2:00:00 PM 100% 1 113ms
8/16/2026, 3:00:00 PM 100% 1 143ms
8/16/2026, 4:00:00 PM 100% 1 55ms
8/16/2026, 6:00:00 PM 100% 1 61ms
8/16/2026, 7:00:00 PM 100% 1 91ms
8/16/2026, 8:00:00 PM 100% 1 142ms
8/16/2026, 9:00:00 PM 100% 1 80ms
8/16/2026, 10:00:00 PM 100% 1 58ms
8/16/2026, 11:00:00 PM 100% 1 56ms
8/17/2026, 1:00:00 AM 100% 1 113ms
8/17/2026, 2:00:00 AM 100% 1 49ms
8/17/2026, 3:00:00 AM 100% 1 53ms
8/17/2026, 4:00:00 AM 100% 1 53ms
8/17/2026, 5:00:00 AM 100% 1 52ms
8/17/2026, 6:00:00 AM 100% 1 59ms
8/17/2026, 8:00:00 AM 100% 1 190ms
8/17/2026, 9:00:00 AM 100% 1 56ms
8/17/2026, 10:00:00 AM 100% 1 71ms
8/17/2026, 11:00:00 AM 100% 1 87ms
8/17/2026, 12:00:00 PM 100% 1 47ms
8/17/2026, 1:00:00 PM 100% 1 61ms
8/17/2026, 3:00:00 PM 100% 1 64ms
8/17/2026, 4:00:00 PM 100% 1 76ms
8/17/2026, 5:00:00 PM 100% 1 58ms
8/17/2026, 6:00:00 PM 100% 1 125ms
8/17/2026, 7:00:00 PM 100% 1 61ms
8/17/2026, 8:00:00 PM 100% 1 94ms
8/17/2026, 10:00:00 PM 100% 1 53ms
8/17/2026, 11:00:00 PM 100% 1 59ms
8/18/2026, 12:00:00 AM 100% 1 68ms
8/18/2026, 1:00:00 AM 100% 1 211ms
8/18/2026, 2:00:00 AM 100% 1 54ms
8/18/2026, 3:00:00 AM 100% 1 53ms
8/18/2026, 5:00:00 AM 100% 1 73ms
8/18/2026, 6:00:00 AM 100% 1 67ms
8/18/2026, 7:00:00 AM 100% 1 45ms
8/18/2026, 8:00:00 AM 100% 1 57ms
8/18/2026, 9:00:00 AM 100% 1 70ms
8/18/2026, 10:00:00 AM 100% 1 62ms
8/18/2026, 12:00:00 PM 100% 1 81ms
8/18/2026, 1:00:00 PM 100% 1 87ms
8/18/2026, 2:00:00 PM 100% 1 89ms
8/18/2026, 3:00:00 PM 100% 1 59ms
8/18/2026, 4:00:00 PM 100% 1 57ms
8/18/2026, 5:00:00 PM 100% 1 53ms
8/18/2026, 7:00:00 PM 100% 1 75ms
8/18/2026, 8:00:00 PM 100% 1 42ms
8/18/2026, 9:00:00 PM 100% 1 61ms
8/18/2026, 10:00:00 PM 100% 1 98ms
8/18/2026, 11:00:00 PM 100% 1 49ms
8/19/2026, 12:00:00 AM 100% 1 58ms
8/19/2026, 2:00:00 AM 100% 1 85ms
8/19/2026, 3:00:00 AM 100% 1 50ms
8/19/2026, 4:00:00 AM 100% 1 93ms
8/19/2026, 5:00:00 AM 100% 1 62ms
8/19/2026, 6:00:00 AM 100% 1 63ms
8/19/2026, 7:00:00 AM 100% 1 274ms
8/19/2026, 9:00:00 AM 100% 1 52ms
8/19/2026, 10:00:00 AM 100% 1 62ms
8/19/2026, 11:00:00 AM 100% 1 87ms
8/19/2026, 12:00:00 PM 100% 1 58ms
8/19/2026, 1:00:00 PM 100% 1 54ms
8/19/2026, 2:00:00 PM 100% 1 50ms
8/19/2026, 4:00:00 PM 100% 1 56ms
8/19/2026, 5:00:00 PM 100% 1 57ms
8/19/2026, 6:00:00 PM 100% 1 50ms
8/19/2026, 7:00:00 PM 100% 1 50ms
8/19/2026, 8:00:00 PM 100% 1 61ms
8/19/2026, 9:00:00 PM 100% 1 75ms
8/19/2026, 11:00:00 PM 100% 1 45ms
8/20/2026, 12:00:00 AM 100% 1 62ms
8/20/2026, 1:00:00 AM 100% 1 187ms
8/20/2026, 2:00:00 AM 100% 1 59ms
8/20/2026, 3:00:00 AM 100% 1 197ms
8/20/2026, 4:00:00 AM 100% 1 66ms
8/20/2026, 6:00:00 AM 100% 1 166ms
8/20/2026, 7:00:00 AM 100% 1 76ms
8/20/2026, 8:00:00 AM 100% 1 57ms
8/20/2026, 9:00:00 AM 100% 1 53ms
8/20/2026, 10:00:00 AM 100% 1 68ms
8/20/2026, 11:00:00 AM 100% 1 67ms
8/20/2026, 1:00:00 PM 100% 1 66ms
8/20/2026, 2:00:00 PM 100% 1 83ms
8/20/2026, 3:00:00 PM 100% 1 237ms
8/20/2026, 4:00:00 PM 100% 1 50ms
8/20/2026, 6:00:00 PM 100% 1 66ms
8/20/2026, 7:00:00 PM 100% 1 60ms
8/20/2026, 8:00:00 PM 100% 1 61ms
8/20/2026, 9:00:00 PM 100% 1 115ms
8/20/2026, 10:00:00 PM 100% 1 315ms
8/20/2026, 11:00:00 PM 100% 1 71ms
8/21/2026, 12:00:00 AM 100% 1 47ms
8/21/2026, 1:00:00 AM 100% 2 59ms
8/21/2026, 2:00:00 AM 100% 1 54ms
8/21/2026, 3:00:00 AM 100% 1 67ms
8/21/2026, 5:00:00 AM 100% 1 75ms
8/21/2026, 6:00:00 AM 100% 1 57ms
8/21/2026, 7:00:00 AM 100% 1 57ms
8/21/2026, 8:00:00 AM 100% 1 54ms
8/21/2026, 9:00:00 AM 100% 1 68ms
8/21/2026, 10:00:00 AM 100% 1 56ms
8/21/2026, 12:00:00 PM 100% 1 66ms
8/21/2026, 1:00:00 PM 100% 1 51ms
8/21/2026, 2:00:00 PM 100% 1 61ms
8/21/2026, 3:00:00 PM 100% 1 220ms
8/21/2026, 4:00:00 PM 100% 1 56ms
8/21/2026, 5:00:00 PM 100% 1 64ms
8/21/2026, 7:00:00 PM 100% 1 74ms
8/21/2026, 8:00:00 PM 100% 2 52ms
8/21/2026, 9:00:00 PM 100% 1 350ms
8/21/2026, 10:00:00 PM 100% 1 226ms
63
Composite reliability — the weighted average of the dimensions below, on a 0–100 scale.
Availability
100

How often it was reachable when we probed it (weight 35%).

Latency
100

How quickly it answers when it is up — fast scores high (weight 20%).

Security
100

Whether it serves over working TLS / https (weight 15%).

Transparency
61

Whether the operator disclosed what it does — description, schema, identity (weight 15%).

Activity
2

Observed on-chain payments to this endpoint's wallet — transactions, volume, and distinct paying wallets over the last month (weight 15%; not yet measured when we have not seen its wallet settle).

Confidence 100% — how much probe evidence backs this score. A thin history is flagged, not hidden.

See the scoring methodology for exactly how each number is computed.

Payment

Currencies
USDC
Networks
base, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp
Facilitator
unknown
SDK
unknown

Operator

Company
inferred — unknown
Jurisdiction
—
Registrar
—
Domain registered
—
Hosting network
VERCEL-09
Hosting country
—

Operator context is derived from public RDAP/TLS records and unverified. Company and country are only available for endpoints that publish them (an OV/EV TLS certificate or a non-redacted domain record); most endpoints are CDN-fronted and disclose neither.

On-chain activity (base)

12,901
payments (30d)
37.05
USD volume (30d)
182
paying wallets (30d)

Payments per day

last payment 8/21/2026
0 1000 2000 Jul 23Aug 2Aug 11Aug 21
Data table
Settled payments per day.
Day Payments Volume (USD) Paying wallets
7/23/2026 629 1.66 89
7/24/2026 1,232 2.49 117
7/25/2026 1,341 2.61 128
7/26/2026 915 1.98 107
7/27/2026 1,175 2.1 107
7/28/2026 762 1.71 86
7/29/2026 852 1.67 97
7/30/2026 818 1.74 97
7/31/2026 882 1.7 94
8/1/2026 633 1.24 82
8/2/2026 604 1.12 76
8/3/2026 358 1.6 47
8/4/2026 530 3.35 70
8/5/2026 408 2.76 42
8/6/2026 272 2.14 32
8/7/2026 164 1.37 23
8/8/2026 127 1.51 17
8/9/2026 60 0.33 10
8/10/2026 109 0.36 8
8/11/2026 84 0.25 8
8/12/2026 84 0.25 6
8/13/2026 73 0.21 6
8/14/2026 167 1.05 6
8/15/2026 24 0.1 4
8/16/2026 338 0.86 2
8/17/2026 63 0.18 3
8/18/2026 55 0.16 2
8/19/2026 84 0.23 3
8/20/2026 43 0.25 6
8/21/2026 15 0.06 5

This payout wallet is shared: figures cover all 442 endpoints paid at it, since payments cannot be attributed to one of them. Only payments settled on chains and facilitators we index.

Linked by wallet — likely same operator

On-chain agent identity and the x402 endpoint that shares its settlement wallet.

https://2s.io/api/crypto/ens-resolve x402 endpoint https://2s-3cpr6qm6j-alleyford.vercel.app/api/convert/unit x402 endpoint
Response schema 
{
  "properties": {
    "data": {
      "additionalProperties": false,
      "properties": {
        "items": {
          "items": {
            "additionalProperties": false,
            "properties": {
              "briefSummary": {
                "nullable": true,
                "type": "string"
              },
              "briefTitle": {
                "nullable": true,
                "type": "string"
              },
              "completionDate": {
                "nullable": true,
                "type": "string"
              },
              "conditions": {
                "items": {
                  "type": "string"
                },
                "type": "array"
              },
              "enrollmentCount": {
                "nullable": true,
                "type": "integer"
              },
              "enrollmentType": {
                "nullable": true,
                "type": "string"
              },
              "hasResults": {
                "type": "boolean"
              },
              "interventions": {
                "items": {
                  "additionalProperties": false,
                  "properties": {
                    "name": {
                      "nullable": true,
                      "type": "string"
                    },
                    "type": {
                      "nullable": true,
                      "type": "string"
                    }
                  },
                  "required": [
                    "type",
                    "name"
                  ],
                  "type": "object"
                },
                "type": "array"
              },
              "lastUpdatePostedDate": {
                "nullable": true,
                "type": "string"
              },
              "leadSponsor": {
                "nullable": true,
                "type": "string"
              },
              "leadSponsorClass": {
                "nullable": true,
                "type": "string"
              },
              "nctId": {
                "type": "string"
              },
              "officialTitle": {
                "nullable": true,
                "type": "string"
              },
              "phases": {
                "items": {
                  "type": "string"
                },
                "type": "array"
              },
              "primaryCompletionDate": {
                "nullable": true,
                "type": "string"
              },
              "startDate": {
                "nullable": true,
                "type": "string"
              },
              "status": {
                "nullable": true,
                "type": "string"
              },
              "studyFirstPostedDate": {
                "nullable": true,
                "type": "string"
              },
              "studyType": {
                "nullable": true,
                "type": "string"
              },
              "url": {
                "format": "uri",
                "type": "string"
              }
            },
            "required": [
              "nctId",
              "briefTitle",
              "officialTitle",
              "status",
              "phases",
              "studyType",
              "conditions",
              "interventions",
              "enrollmentCount",
              "enrollmentType",
              "startDate",
              "primaryCompletionDate",
              "completionDate",
              "leadSponsor",
              "leadSponsorClass",
              "hasResults",
              "studyFirstPostedDate",
              "lastUpdatePostedDate",
              "briefSummary",
              "url"
            ],
            "type": "object"
          },
          "type": "array"
        },
        "meta": {
          "additionalProperties": false,
          "properties": {
            "nextPageToken": {
              "nullable": true,
              "type": "string"
            },
            "query": {
              "additionalProperties": false,
              "properties": {
                "country": {
                  "nullable": true,
                  "type": "string"
                },
                "nctId": {
                  "nullable": true,
                  "type": "string"
                },
                "pageSize": {
                  "type": "integer"
                },
                "phase": {
                  "nullable": true,
                  "type": "string"
                },
                "query": {
                  "nullable": true,
                  "type": "string"
                },
                "sponsor": {
                  "nullable": true,
                  "type": "string"
                },
                "status": {
                  "nullable": true,
                  "type": "string"
                }
              },
              "required": [
                "query",
                "nctId",
                "status",
                "sponsor",
                "phase",
                "country",
                "pageSize"
              ],
              "type": "object"
            }
          },
          "required": [
            "query",
            "nextPageToken"
          ],
          "type": "object"
        },
        "ok": {
          "enum": [
            true
          ],
          "type": "boolean"
        },
        "source": {
          "$ref": "#/components/schemas/Source"
        },
        "total": {
          "description": "Total matching rows upstream; null when unknown.",
          "nullable": true,
          "type": "integer"
        }
      },
      "required": [
        "ok",
        "items",
        "total",
        "source"
      ],
      "type": "object"
    },
    "meta": {
      "$ref": "#/components/schemas/CallMeta"
    }
  },
  "required": [
    "data",
    "meta"
  ],
  "type": "object"
}